Kit for the LC-MS/MS analysis of the Endogenous GAG NRE Biomarkers: UA-HNAc(1S)-Early and UA-HNAc(1S)-Late. These GAG NREs have been cited in literature (Herbst et. al. 2020 & Herbst et. al. 2022) as useful for second tier screening of MPS-I and MPS-II*.
The Kit includes the following QCs and Reagents for 3,000 Assays:
- 1 Vial of Internal Standard for 3,000 Assays (product BM14A);
- 75 Vials of Derivatization Reagent for 50 Assays;
- 1 QC "Negative" DBS Card (10 Spots, 60 punches);
- 1 QC "High" IDUA Deficiency DBS Card (10 Spots, 60 punches) (product QCEG-1);
- 1 QC "High" I2S Deficiency DBS Card (10 Spots, 60 punches) (product QCEG-2).
Endogenous GAG NRE Biomarker Kit (IDUA & I2S Deficiencies)
Herbst, Z.M., Urdaneta, L., Klein, T., Fuller, M. and Gelb, M.H., 2020. Evaluation of multiple methods for quantification of glycosaminoglycan biomarkers in newborn dried blood spots from patients with severe and attenuated mucopolysaccharidosis-I. International journal of neonatal screening, 6(3), p.69.
Herbst, Z.M., Urdaneta, L., Klein, T., Burton, B.K., Basheeruddin, K., Liao, H.C., Fuller, M. and Gelb, M.H., 2022. Evaluation of two methods for quantification of glycosaminoglycan biomarkers in newborn dried blood spots from patients with severe and attenuated mucopolysaccharidosis Type II. International Journal of Neonatal Screening, 8(1), p.9.