Endogenous Glycosaminoglycan (GAG) Disaccharide, "UA-HNAc(1S)-Early," prepared with blood from a healthy adult. Product consists of one QC High DBS card prepared with blood from a healthy adult spiked with the Endogenous Disaccharide, "UA-HNAc (1S)-Early." One control DBS card prepared with unspiked blood is also provided. Each DBS card contains ten DBS. At least five to six 3 mm punches can be taken from each DBS.
The Endogenous GAG Disaccharide, "UA-HNAc(1S)-Early," was described by Herbst et. al. as being elevated in 15 MPS-I Newborn DBS (IDUA deficiency) when compared to a reference range. Newborns with both the severe and attenuated forms of MPS-I were included (Hurler Syndrome and Scheie Syndrome).
Endogenous GAG Biomarker "UA-HNAc(1S)-Early" QC DBS
Herbst, Z.M., Urdaneta, L., Klein, T., Fuller, M., Gelb, M.H., 2020. Evaluation of Multiple Methods for Quantification of Glycosaminoglycan Biomarkers in Newborn Dried Blood Spots from Patients with Severe and Attenuated Mucopolysaccharidosis-I. International journal of neonatal screening, 6(3), p.69.