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Endogenous Glycosaminoglycan (GAG) Disaccharide, "UA-HNAc(1S)-Early," prepared with blood from a healthy adult. Product consists of one QC High DBS card prepared with blood from a healthy adult spiked with the Endogenous Disaccharide, "UA-HNAc (1S)-Early." One control DBS card prepared with unspiked blood is also provided. Each DBS card contains ten DBS. At least five to six 3 mm punches can be taken from each DBS.


*The Endogenous GAG Disaccharide, "UA-HNAc(1S)-Early," was described by Herbst et. al. as being elevated in 15 MPS-I Newborn DBS (IDUA deficiency) when compared to a reference range. Newborns with both the severe and attenuated forms of MPS-I were included (Hurler Syndrome and Scheie Syndrome).


Internal Standard sold separately (product BM14A).

Endogenous GAG NRE Biomarker "UA-HNAc(1S)-Early" QC DBS

  • Herbst, Z.M., Urdaneta, L., Klein, T., Fuller, M., Gelb, M.H., 2020. Evaluation of Multiple Methods for Quantification of Glycosaminoglycan Biomarkers in Newborn Dried Blood Spots from Patients with Severe and Attenuated Mucopolysaccharidosis-I. International journal of neonatal screening, 6(3), p.69.

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